Evaluating the relationship of high-dose venlafaxine prescribing to treatment-resistant depression
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چکیده
AIMS AND METHOD Prescribing of venlafaxine inThe South London and Maudsley NHS Trust was found to account for over 50% of the antidepressant costs, but only 15% of the prescriptions.There is evidence to suggest that higher doses of venlafaxine may be effective in treating treatment-refractory depression.We aimed to discover if higher doses of venlafaxine used in the trust were related to prior failure to respond to antidepressant treatment. Hospital in-patients being treated with venlafaxine during a 1-week period in October 2001were identified and case notes were reviewed to determine patient demographic data and prior history of antidepressant therapy.
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Dose-response relationship of recent antidepressants in the short-term treatment of depression
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Patients 123 patients (mean age 43 y, 72% women) with major depression (DSM-III-R) of < 8 months duration. Inclusion criteria were age 18–60 years, 17-item Hamilton Depression Rating Scale (HDRS) score >18 and resistance (Clinical Global Impression [CGI] scale improvement score of 3 at the second treatment) to 2 antidepressant treatments for the current depression (therapeutic dose for >4 wk, t...
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